The latest university kratom research published review of 27 years of international scientific evidence, written by researchers at the University of Rochester Medical Center (URMC) and the University of British Columbia, may help remove misconceptions about kratom and restore its potential as As the use of kratom in the Western world has grown during the past 15 years, there have been increased efforts to identify and characterize the active pharmacologic agents that mediate the effects of white maeng da kratom in the body. Thus far, more than 20 active alkaloids or compounds have been isolated from kratom powder, and considerable evidence shows that these compounds do, in fact, have major pharmacologic effects. Various aspects of the medicinal chemistry and pharmacognosy of red dragon kratom have recently been reviewed by Accordingly, only a few key points regarding these topics will be considered in the present article. The Table shows the chemical alkaloid structures and summarizes the major pharmacologic actions of some of the best kratom-derived compounds that have been studied most extensively by scientists. The most extensively-characterized of kratom’s active pharmacologic agents have been the mitragynine analogs. These agents contain an indole ring and are, in some respects, structurally similar to yohimbine. These kratom alkaloids have been shown to produce a wide variety of pharmacologic effects, both in vivo and in vitro. In the following sections, we will consider the importance of these compounds as they relate to the primary pharmacologic effects of white kratom, particularly analgesia and the ability of home remedies for opiate withdrawal.