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Interesting CBD Reddit Posts

Marijuana leaf and cereal crunchy multigrain chocolate on brown wooden background.

CBD isolate only contains pure CBD and no other compounds. Full spectrum CBD gummies on the other hand contains CBD plus all the other compounds found in hemp such as THC, CBN, CBG etc. The amount of THC in full spectrum products is so low that you will not get the psychoactive high that is associated with it. Research shows there is more medicinal power behind CBD full spectrum products due to something called the entourage effect. All the cannabinoids work together. CBD by itself still has medicinal properties but the effective dose is narrow and limited. Hope this helps!

Can you elaborate on how it messed up your sleep, and whether it was full-spectrum or isolate? It could be that one will work better than the other for your specific ailment.

One thing I have noticed about CBD edibles products, even when they are similar product types and they come from reputable vendors, is that the effects vary dramatically. I think it comes down to each person’s metabolism, body chemistry, and endocannabinoid system, etc. For me this has meant tons of research and also experimentation to find out what works for me. So far I have found full-spectrum tinctures to be helpful for general well-being and calmness, full-spectrum vape carts/flower for bad pain or headaches, and isolate-based edibles for back pain and stuff where I want relief but also need to be really functional. But this differs quite a bit for each person!

Some other thoughts:

-You might give topicals a try if there are specific parts of your body that hurt (like hands and feet). There are some fairly affordable full-spectrum options out there.

-For some people, there are side effects that subside once their bodies get used to the CBD intake. Not saying you should tough it out if you aren’t seeing benefits, but if you are getting pain relief from CBD oil, you might try sticking with it for a bit to see if your sleep regulates after a while.

-Like I mentioned above, some folks get better results with isolate vs. full spectrum, or vice versa (general consensus is that full spectrum is king, but it’s not the case for everyone). Some people have reported that CBD isolate will make them feel more alert or even keep them up at night, so if you used isolate and had trouble sleeping that could be it.

-When in doubt, try smoking a tiny bit of flower from a reputable vendor and see if that helps! I save flower for very bad pain or intolerable headaches, but it works like a freaking charm, and fast too.

Sorry for the wall of text, still drinking my morning coffee and kind of scatterbrained. Hope some of this was helpful and hope you can find some relief!

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Kratom Research Grant

“Chris McCurdy was a pioneer in the area of kratom for pain research 10 years ago,” McMahon said. “This NIDA grant shows interest in the potential of kratom-based medicines, as well as concerns over the potential misuse of kratom-related substances.”

The National Institute on Drug Abuse has awarded researchers at the University of Florida College of Pharmacy a two-year, $3.5 million grant to bolster research on Mitragyna speciosa, or kratom, and its potential to treat opioid misuse and physical dependence.

UF College of Pharmacy scientific researchers have studied all strains kratom, which comes from the leaves of a tropical tree from Southeast Asia, as a potential therapy to wean addicts off heroin or prescription opioids. It activates the same opioid receptors and appears to satisfy the craving, while possibly lessening the risk of respiratory depression.

Next the lab researchers will seek to identify the pharmacology of its 40 alkaloids, test the effects of these individual alkaloids on the brain’s receptors and continue to develop treatment strategies to help addicts quit opioids.

Principal scientific research investigators Lance McMahon., a professor and chair of the college’s department of pharmacodynamics, and Chris McCurdy, Ph.D., a professor of medicinal chemistry in the highest ranked college, say the grant will renew and reinvigorate their research.

Estimates show between 10 million and 14 million people in the United States use red strains of kratom, although the substance is poorly understood.

“Many government agencies have a vested interest in the grant, including the NIDA, the National Institutes of Health, the Drug Enforcement Administration and the Food and Drug Administration. McMahon, McCurdy and their team have monthly meetings with the NIDA program officers to discuss progress of the UG3/UH3 grant.”

With new grant funding for kratom research made possible by this and other grants, the size of the research team and infrastructure to study kratom have expanded. Quantities of kratom samples that once took two to three months to generate can now be available in just one week.

The next stage of kratom research involves identifying the pharmacology of its chemicals. Bonnie Avery, Ph.D., a key co-investigator and clinical professor of pharmaceutics at the college, identifies kratom’s alkaloids through chromatographic methods, to determine where they go in the body and how they are broken down into metabolites.

After that, McMahon and Jay McLaughlin, Ph.D., an associate professor of pharmacodynamics, run in vivo pharmacodynamics tests to determine the effects of individual kratom alkaloids on receptor targets in the brain.

The scientific team will continue developing treatment strategies to wean addicts off opioids, similar in the way the classically accepted drugs, buprenorphine and methadone, are currently prescribed. Although less dangerous than heroine and other prescription opioids, they are narcotics with the potential to be abused, which is why researchers are interested in safer alternatives.

The last main research objective is for McCurdy to change a natural substance in kratom to reduce symptoms of opioid withdrawal.

Other members of the research team include research scientist Francisco Leon, Ph.D., and research assistant professors Jenny Wilkerson, Ph.D., and Takato Hiranita, Ph.D.

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Kratom Answers

The latest university kratom research published review of 27 years of international scientific evidence, written by researchers at the University of Rochester Medical Center (URMC) and the University of British Columbia, may help remove misconceptions about kratom and restore its potential as As the use of kratom in the Western world has grown during the past 15 years, there have been increased efforts to identify and characterize the active pharmacologic agents that mediate the effects of white maeng da kratom in the body. Thus far, more than 20 active alkaloids or compounds have been isolated from kratom powder, and considerable evidence shows that these compounds do, in fact, have major pharmacologic effects. Various aspects of the medicinal chemistry and pharmacognosy of red dragon kratom have recently been reviewed by Accordingly, only a few key points regarding these topics will be considered in the present article. The Table shows the chemical alkaloid structures and summarizes the major pharmacologic actions of some of the best kratom-derived compounds that have been studied most extensively by scientists. The most extensively-characterized of kratom’s active pharmacologic agents have been the mitragynine analogs. These agents contain an indole ring and are, in some respects, structurally similar to yohimbine. These kratom alkaloids have been shown to produce a wide variety of pharmacologic effects, both in vivo and in vitro. In the following sections, we will consider the importance of these compounds as they relate to the primary pharmacologic effects of white kratom, particularly analgesia and the ability of home remedies for opiate withdrawal.

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Science Of Natural Kratom Remedies

A new study published online December 15 by the Journal of Psychoactive Drugs found regular maeng da kratom users suffered no significant cognitive impairment.

The research study, conducted by kratom scientist Darshan Singh and other university scientists, focused on 1000 self-reported users of the herbal supplement kratom, sold online and in smoke shops around the U.S., Johns Hopkins Medicine scientific researchers conclude that the psychoactive compound somewhat similar to opioids likely has a lower rate of harm than prescription opioids for treating pain, anxiety, depression and addiction.

In a report on the study’s findings, published in the Feb. 3 issue of Drug and Alcohol Dependence, the lab researchers caution that while self-reporting surveys aren’t always entirely reliable, they confirmed that kratom is not regulated or approved by the FDA, and that peer reviewed scientific studies have not been done to formally establish safety and health benefits. They say that U.S. drug agencies should seek to study and regulate rather than ban kratom sales outright because of its seemingly safe therapeutic potential, and as a possible alternative to opioid use.

The American Kratom Association, estimates that 10-16 million people in the U.S. regularly use kratom by either taking capsules, powder, eating its ground leaves in food or brewing them in tea. Kratom is a tropical plant related to coffee trees, and grown mainly in Southeast Asia. It contains a chemical called mitragynine, an alkaloid that acts on the brain opiate receptors and alters mood. In Asia, where use has long been widespread, people, mostly farmers use it in small doses as an energy and mood booster, similar to coffee use in the West. They use larger amounts for pain, or recreationally like beer and wine.

For the current survey, Garcia-Romeu says, he and his team enrolled 2,798 people to complete an online survey on their use of white maeng da kratom. They recruited participants online and through social media, as well as through the AKA. Overall, users were mostly white, educated and middle-aged. Some 61% of users were women, and 90% were white. About 6% reported being multiracial, 1.5% reported being Native American or Hawaiian, 0.5% reported being Asian and 0.4% said they were African American. Participants were an average age of 40. About 84% of participants reported having at least some college education.

Of these participants, 91% reported taking maeng da kratom to alleviate pain on average a couple times a day for back, shoulder and knee pain, 67% for anxiety and 65% for depression. About 41% of survey responders said they took kratom to treat opioid withdrawal, and of those people who took it for opioid withdrawal, 35% reported going more than a year without taking prescription opioids or heroin. “Although our findings show kratom powder to be relatively safe according to these self-reports, unregulated medicinal natural supplements raise concerns with respect to contamination or higher doses of the active chemicals, which could increase negative side effects and harmful responses,” says Garcia-Romeu. “This is why we advocate for the FDA to regulate kratom, which would require testing for impurities and maintaining safe levels of the active chemicals. Otherwise, unregulated kratom products run the risk of unsafe additives and dosing problems, which could be like getting a shot of grain alcohol when you were trying to order a beer.”

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